Genetic Mutations
161 articles
Having a genetic mutation can make all the difference in treatment choices, and even longer-term survival. Learn more about the importance of genetic testing and molecular profiling.
Targeting the Undruggable KRAS Protein
Dr. Shubham Pant is focusing his research on effective treatments for the KRAS mutation, found in 90% of pancreatic cancers.
Earlier Detection of Pancreatic Cancer: A Marathon, Not A Sprint
Dino Verrelli of Project Purple joins with Dr. Diane Simeone on the PRECEDE Consortium to develop earlier detection and new pancreatic cancer treatments.
Focusing on a Drug that Treats Specific Tumor Mutations
A clinical trial tests a signal-inhibiting drug for lung cancers with specific genetic mutations on gastrointestinal cancers with the same tumor mutations.
Could AI Help Detect the Pancreatic Cancers We Usually Miss?
Dr. Ajit Goenka is leading a team at the Mayo Clinic that is exploring how AI can be used to find random pancreatic cancer.
Will New-Onset Diabetes Provide a Way to Detect Pancreatic Cancer Earlier?
Dr. Anirban Maitra, Dr. Suresh Chari, and others are looking at the relationship between new-onset diabetes and pancreatic cancer.
New Drug for BRCA Carriers with Advanced Cancer
A phase I clinical trial is testing the effectiveness of a platinum-based drug for BRCA carriers with pancreatic, breast, and other cancers.
Tumor Biology Matters
Dr. Lynn Matrisian of PanCAN, explains that molecular profiling of a pancreatic cancer patient’s tumor can show which treatment will work best.
KRYSTAL-1 Trial Shows Promising Activity in Pancreas and Other GI Cancers
Dr. Tanios Bekaii-Saab reports promising results of the KRYSTAL-1 trial, which targets a KRAS mutation common to pancreatic cancer.
CRISPR: A New Tool to Help Understand Cancer-Linked Mutations
Lukas Dow, Ph.D., is using CRISPR technology to find better ways to fight cancer by editing the genome.
Cracking the KRAS Code
Dr. Despina Siolas is focusing her research on new treatments for pancreatic cancer, particularly ones that go after KRAS mutations.
Clinical Trial For OncoTreat Being Developed
Researcher Kenneth Olive is developing OncoTreat, a method matches a patient’s tumor to the most effective drugs for their pancreatic cancer.
Testing a Signal-Inhibiting Drug on Tumors with Specific Mutations
A new drug for certain tumor mutations is being tested in a type of clinical trial called a basket trial, which matches tumor genetics and drugs.
Newly Discovered Protein Complex in RAS Pathway May Provide a Treatment Target
Dr. Andrew Aguirre and other researchers from Dana-Farber and the Broad Institute are looking at the RAS pathway for a new target.
A Look at MEK and Autophagy Inhibition
Dr. Conan Kinsey looks at the MEK pathway as way to make immunotherapy more effective for pancreatic cancer patients.
MRI-Guided Radiation: A New Option for Pancreatic Cancer Treatment
Dr. Parag Parikh and others are using MRI-guided radiation to provide precision radiation treatment for pancreatic cancer.