Genetic Mutations and Family History

37 Articles

Dr. Alison Klein, pancreatic cancer researcher
Research
November 7, 2022 • 6 Min

Putting Familial Risk In Perspective

Dr. Alison Klein works to understand the relationship between familial risk and the chances of developing pancreatic cancer.

Dr. Nicolette Rodriguez
Research
October 25, 2022 • 5 Min

Meet the Researcher: Nicolette Juliana Rodriguez, M.D., M.P.H.

Learn more about the research interests of Nicolette Rodriguez, M.D., M.P.H., one of the young investigators Let’s Win sponsored at AACR.

Dr. Andrew Aguirre
Research
September 29, 2022 • 4 Min

Newly Discovered Protein Complex in RAS Pathway May Provide a Treatment Target

Dr. Andrew Aguirre and other researchers from Dana-Farber and the Broad Institute are looking at the RAS pathway for a new target.

bright colored yellow, red, and green dots in square patterns on a black background
Research
June 17, 2022 • 3 Min

New Gene Inhibitor Drug for Patients with MTAP-Deleted Tumors

A new trial targets patients with advanced solid tumors, including pancreatic cancer, with an MTAP-deletion genetic mutation.

Dr. Nicolette Rodriguez
Research
March 21, 2022 • 5 Min

New Study to Get More Minorities Involved in Genetic Testing

Dr. Nicolette Rodriguez leads the REGENERATE study to find the best ways to get more Black and Latinx Americans genetic testing for cancer.

black and white photo of DNA reading
Research
March 11, 2022 • 2 Min

Testing an Approved Drug for a Specific Mutation

Researchers are testing a drug combination for melanoma in pancreatic cancer patients with a BRAF genetic mutation.

Kim Reiss Binder
Research
January 12, 2022 • 5 Min

New Study Aims to Reduce Recurrence Risk for Select Patients

Dr. Kim A. Reiss is leading a study of the PARP inhibitor olaparib to delay or prevent a recurrence of surgically removed pancreatic cancer.

DNA image
Research
November 22, 2021 • 2 Min

Using Molecular Tumor Profiling to Determine the Best Pancreatic Cancer Treatment

A clinical trial looks at whether molecular subtyping of tumors is effective in determining the best pancreatic cancer treatment.

Dr. Pant Subhan
Research
September 1, 2021 • 5 Min

Targeting the Undruggable KRAS Protein

Dr. Shubham Pant is focusing his research on effective treatments for the KRAS mutation, found in 90% of pancreatic cancers.

orange and blue kaleidoscopic pattern
Research
August 11, 2021 • 2 Min

Testing a PARP Inhibitor for Metastatic Pancreatic Cancer Patients with DNA Repair Mutations

Researchers are testing a PARP inhibitor that is effective for cancers in pancreatic cancer patients with DNA repair mutations.

abstract DNA image in bright greens and reds
Research
May 25, 2021 • 2 Min

PARP Inhibitor as Maintenance for Pancreatic Cancer Patients with BRCA1, BRCA2, or PALB2 Mutations

A new clinical trial tests a PARP inhibitor as maintenance treatment for pancreatic cancer patients with BRCA1/2 or PALB2 mutations.

multicolored abstract DNA against a black background
Research
April 29, 2021 • 3 Min

Chemotherapy Plus Stem Cell Infusion and Vitamins for BRCA Mutated Pancreatic Cancer

A clinical trial for pancreatic cancer patients with a BRCA mutation uses a combination of chemotherapy, vitamins, and stem cells.

Angela Bradbury MD
Research
April 26, 2021 • 5 Min

Improving Access to Genetic Testing and Counseling

Dr. Angela Bradbury is leading a study on access to genetic testing and genetic counseling, including a telehealth option.

Dr. Sapna Syngal
Research
July 2, 2020 • 4 Min

GENERATE Trial Expands Eligibility

Dr. Sapna Syngal explains the expanded eligibility standards for the GENERATE Study for genetic testing of pancreatic cancer patients and relatives.

Dr. Beatriz Carreno
Research
April 16, 2020 • 5 Min

Targeting Mutant KRAS with Immunotherapy

Dr. Beatriz Carreno explains how her team is targeting the KRAS mutation with a pancreatic cancer vaccine to make the immune system work against cancer.