Genetic Mutations
159 articles
Having a genetic mutation can make all the difference in treatment choices, and even longer-term survival. Learn more about the importance of genetic testing and molecular profiling.
Early Detection Trial for People at Higher Risk of Pancreatic Cancer
Relatives of pancreatic cancer patients or people who carry certain mutations can participate in an early detection clinical trial.
A Registry for Those at Risk for Pancreatic Cancer
Dr. Robert Kurtz founded the Pancreatic Tumor Registry at Memorial Sloan Kettering to learn more about the genetic mutations that cause pancreatic cancer.
The Latest Research from the 2025 AACR Special Conference
Highlights from the 2025 AACR Special Conference on pancreatic cancer research include updates on drugs that work on KRAS, AI and early detection, and biomarkers.
Treating BRCA-Negative Pancreatic Cancer Patients with a Family Cancer History Similar to BRCA Carriers
A clinical trial looks at the effectiveness of a PARP inhibitor in BRCA-negative pancreatic cancer patients with a family history BRCA-type cancers.
Rewinding 2025: A Year in Pancreatic Cancer Research
We take a look back at the research developments in 2025: KRAS, earlier detection and screening, vaccines, and clinical trials.
An Expanded Access Trial for Cancer Patients with Specific Mutations
An investigational drug is being used in an expanded access trial for advanced pancreatic and other cancer patients with specific genetic changes.
CRISPR: A New Tool to Help Understand Cancer-Linked Mutations
Lukas Dow, Ph.D., is using CRISPR technology to find better ways to fight cancer by editing the genome.
RNA Precision Trial for Pancreatic Cancer Opens At Columbia
Dr. Andrea Califano leads a precision oncology clinical trial of the OncoTreat platform, which looks at proteins to determine treatment.
Comprehensive Molecular Test Helps Classify Pancreatic Cysts
Dr. Aatur Singhi and colleagues are developing a test to help determine whether pancreatic cysts are likely to turn cancerous.
Representing Genetic and Clinical Diversity in Pancreatic Cancer
Dr. Kentaro Sudo explores the possible causes for different responses to drugs among ethnic groups, pointing to the need for clinical diversity in trials.
Testing Vitamin C as a Cancer Killer
Lewis Cantley’s team is starting clinical trials of vitamin C to gain more information about its role in stopping cancer.
Finding More Clues about Circulating Tumor DNA
Researcher Dr. Gehan Botrus looks at circulating tumor DNA for genetic information on a patient’s pancreatic cancer to personalize treatment.
Can a Pancreatic Cancer Screening Test Become a Reality?
Dr. Felice Schnoll-Sussman discusses screening options for pancreatic cancer and criteria for people who might want to get screened.
Testing a PARP Inhibitor for Metastatic Pancreatic Cancer Patients with DNA Repair Mutations
Researchers are testing a PARP inhibitor that is effective for cancers in pancreatic cancer patients with DNA repair mutations.
Targeting the Undruggable KRAS Protein
Dr. Shubham Pant is focusing his research on effective treatments for the KRAS mutation, found in 90% of pancreatic cancers.