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Researchers Identify New Cell Subtype in Early-Stage Pancreatic Cancer

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The lab of Kathy DelGiorno, assistant professor of cell and developmental biology, seeks to understand changes in the pancreas in response to injury and disease. In a recent project led by graduate student Leah Caplan, also from the Department of Cell and Developmental Biology, the lab investigated the formation of enteroendocrine cells—a collection of gastrointestinal and pancreatic cell types that secrete hormones in response to chemical or mechanical stimuli—throughout pancreatic tumor development.

In a recent paper published in Frontiers in Physiology, the researchers used histopathological analyses, genetically engineered animal models and human samples to quantify the subtypes of EECs throughout the development of pancreatic tumors. This work acknowledged the diversity within this cell population and sought to understand how different quantities of each EEC subtype could contribute to disease progression. Read more . . . 

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