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Targetable Landscape in Pancreatic Cancer Varies Greatly by KRAS Status

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Potentially targetable oncogenic rearrangements are more prevalent among patients with KRAS wild-type pancreatic cancer than those with KRAS-mutated disease, according to study results presented at ASCO Annual Meeting.

Homologous recombination deficiency, high tumor mutation burden and microsatellite instability-high disease also appeared more common in the KRAS wild-type population.In addition, early-onset pancreatic cancers — those diagnosed before age 50 years — appeared more likely to be KRAS wild-type, exhibit homologous recombination deficiency phenotype and have germline BRCA1/BRCA2 alterations.  Read more . . . 

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