New research in mice has shed light on how antibodies could be harnessed to puncture the shield of scarlike cells that protect pancreatic cancer from treatment.The knowledge that cells called cancer-associated fibroblasts (CAFs) make up a significant portion of pancreatic tumors is nothing new. These scarlike cells can make tumors dense and tough, blocking chemotherapies and other anti-cancer treatments from reaching the cancer cells.[/sub head]
Previous research by Huocong Huang, M.D., Ph.D. and others at the University of Texas Southwestern Medical Center had already revealed that these CAFs fell into three groups, one known as antigen-presenting CAFs (apCAFS). Read more . . .