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New Evidence Reveals a Cancer-Promoting Role for MAPK6 Enzyme

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A team led by scientists at Baylor College of Medicine uncovered new evidence supporting a cancer-promoting role for enzyme MAPK6. The study, published in the journal Science Advances, shows that MAPK6 furthers cancer growth by activating the AKT pathway, a known cancer-promoting cellular mechanism. The findings suggest that therapies directed at interfering with MAPK6 activity in cancer may offer an effective treatment approach for this condition.Yang and his colleagues began by investigating the effect of overexpressing the MAPK6 gene in normal human prostate or breast epithelial cells grown in the lab.

“We found that overexpressing MAPK6 can transform normal cells into tumor-like cells,” said Yang, a member of Baylor’s Dan L Duncan Comprehensive Cancer Center. “In addition, enhancing MAPK6 expression in prostate, ovarian, breast and non-small cell lung cancer cell lines that already had low to high levels of MAPK6 further promoted growth of all tumor cell lines.” Read more . . . 

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