A new approach to ‘prime’ the tumor environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer.In preclinical models, a team at the Garvan Institute of Medical Research could enhance the tumors’ response to chemotherapy by reducing the stiffness and density of the connective tissue known as the stroma, and reduce cancer spread by up to 50%.
The research has paved the way to a clinical trial that will assess whether the therapy approach will be effective for pancreatic ductal adenocarcinoma patients. Read more . . .