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New discovery Elucidates the Link Between Inflammation and Pancreatic Cancer Development

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A new discovery from researchers at The University of Texas MD Anderson Cancer Center has clarified the long-established connection between inflammation and pancreatic cancer development. According to the study published today in Science, pancreatic cells display an adaptive response to repeated inflammatory episodes that initially protects against tissue damage but can promote tumor formation in the presence of mutant KRAS. {/subhead}

The authors demonstrated that mutant KRAS -; which is found in roughly 95% of all pancreatic cancers -; supports this adaptive response, leading to selective pressure to maintain the cancer-causing mutation. Inflammation has long been linked to tumor development in several cancer types, but the specific reasons behind this connection were previously unclear. Read more . . . 

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