Researchers at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers. The findings show, for the first time, that tissue-specific genetic interactions are responsible for the differential susceptibility of the biliary and the pancreatic epithelium towards transformation by oncogenes.
The study has been published in Cancer Discovery 2021. The research team hopes that these findings could lead to more precise therapeutic decision making in the future. Read more . . .