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New Pancreatic Cancer Therapy Target Discovered

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New research by scientists at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center and with collaborators at the University of Pennsylvania, demonstrates that lowering levels of the hormone PTHrP can prevent metastases and improve survival in mice with pancreatic cancer.

“Pancreatic cancer metastasis is a leading cause of cancer-related deaths, yet very little is understood regarding the underlying biology,” wrote the researchers. “As a result, targeted therapies to inhibit metastasis are lacking. Here, we report that the parathyroid hormone–related protein (PTHrP encoded by PTHLH) is frequently amplified as part of the KRAS amplicon in patients with pancreatic cancer.” Read more . . . 

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