While many genetic alterations have been tied to disease, how these changes lead to disease phenotypes has often not been clear. In a study published on Monday in Nature Genetics, researchers from Harvard Medical School and elsewhere examined the effect of disease-associated alteration on protein networks. Read more . . .
Disease-linked mutations, including both somatic mutations found in tumors and germline variants, are more likely to disrupt protein-protein interactions than other types of variants, a new study has found.