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Disease-Linked Mutations May Affect Protein-Protein Interactions, Influence Drug Response

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Disease-linked mutations, including both somatic mutations found in tumors and germline variants, are more likely to disrupt protein-protein interactions than other types of variants, a new study has found.

While many genetic alterations have been tied to disease, how these changes lead to disease phenotypes has often not been clear. In a study published on Monday in Nature Genetics, researchers from Harvard Medical School and elsewhere examined the effect of disease-associated alteration on protein networks. Read more . . . 

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