Research Into ‘Cold’ Tumors Heating Up in Pancreatic Cancer

Immunotherapy has changed the treatment paradigm for cancer, inducing durable responses in a subset of patients with previously refractory disease. However, current approaches are successful in only approximately 20% of cancers (so-called hot tumors). For the nearly 80% of cancers that are “cold” with weakly active immunity and few intratumoral T cells, immunotherapy has been largely ineffective.