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Mesenchymal plasticity regulated by Prrx1 drives aggressive pancreatic cancer biology

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Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma. Cancer-associated fibroblasts (CAFs) have been shown to display a high degree of interconvertible states including quiescent, inflammatory and myofibroblastic phenotypes, however, the mechanisms by which this plasticity is achieved are poorly understood.

Here, we aim to elucidate the role of CAF plasticity and its impact on PDAC biology. Read more . . . 

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