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Significance of Lymphocyte Recovery From Treatment-Related Lymphopenia in Locally Advanced Pancreatic Cancer

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Radiation-induced lymphopenia is associated with poor prognosis in resected pancreatic cancer and locally advanced pancreatic cancer. However, whether lymphocyte recovery contributes to pancreatic cancer prognosis has not been well-investigated.
We evaluated 497 locally advanced pancreatic cancer patients who underwent concurrent chemoradiotherapy (CCRT). Complete blood counts of patients were obtained before, during, and after CCRT until the 12-month follow-up visit. Patients were categorized into 3 groups according to the development of and recovery from ASL: no ASL (group A, n=198), recovery from ASL (group B, n=141), and no recovery from ASL (group C, n=89). Prognostic factors of overall survival (OS) and progression-free survival (PFS) were determined using Cox regression analyses. Read more . . . 

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