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Halting Pancreatic Cancer Growth by Activating Estrogen Receptor on Cell Surface

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Activating the G protein-coupled estrogen receptor (GPER) – a receptor found on the surface of many normal and cancer tissues – has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy. Researchers at the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center observed the effects of GPER activation in human and mouse pancreatic cancer models and published their findings in Cellular and Molecular Gastroenterology and Hepatology today.

For most cancer types, including pancreas, women generally have better outcomes than men. Although the reasons for this are only now emerging, researchers have known for decades that there is a link between the body’s sex hormones and some types of cancer, especially those arising in reproductive tissues such as breast and prostate. Read more  . . .

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