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Human Pancreatic Cancer Cells Undergo Profound Metabolic Reprogramming Towards Cellular Stemness as Adaptation to Inhibition of the AKT Pathway

Human Pancreatic Cancer Cells Undergo Profound Metabolic  Reprogramming Towards Cellular Stemness as Adaptation to Inhibition of the AKT Pathway
Cancer cells acquire resistance to cytotoxic therapies targeting major survival pathways by adapting their metabolism.

The AKT pathway is a major regulator of human pancreatic adenocarcinoma progression. The mechanisms of adaptation to long-term silencing of AKT isoforms of pancreatic cancer cells were studied.

Following silencing, cancer cells remained quiescent for long periods of time, after which they recovered proliferative capacities. Adaptation caused profound proteomic changes largely affecting mitochondrial biogenesis, energy metabolism, and acquisition of a number of distinct cancer stem cell (CSC) characteristics depending on the AKT isoform that was silenced. Read more . . . 


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