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Nivolumab/Cabiralizumab Combo Misses PFS Endpoint in Pancreatic Cancer

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The combination of nivolumab (Opdivo) and the investigational CSF-1R inhibitor cabiralizumab with and without chemotherapy did not improve progression-free survival (PFS) compared with chemotherapy alone in patients with advanced pancreatic cancer, missing the primary endpoint of a phase II trial (NCT03336216).1

Additionally, no new safety signals were observed in the study. Five Prime Therapeutics, the developer of cabiralizumab, stated in a press release that Bristol-Myers Squibb (BMS), the company manufacturing nivolumab, has no near-term plans for additional sponsored development of cabiralizumab.  Read more . . .

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