The phase II SWOG S1505 study examined early control of systemic pancreatic disease with neoadjuvant treatment with either modified (mFOLFIRINOX) or gemcitabine/nab-paclitaxel (Abraxane) in patients with resectable pancreatic ductal adenocarcinoma. Of the 147 patients who were initially enrolled, 29% were ineligible due to venous involvement, arterial involvement, and distant disease. Results showed that following neoadjuvant chemotherapy, 77% of patients went to surgery and 73% of them underwent resection. Read more . . .
Aggressively treating pancreatic cancer in the neoadjuvant setting with chemotherapy could improve disease control and increase resection rates, explained Davendra Sohal, MD, MPH, citing results of a recent National Clinical Trials Network phase II trial.