“We’ve been thinking about ways to augment T-cell priming to poorly immunogenic tumors,” said Dougan. “Checkpoint blockade operates by de-inhibiting T cells. You can take the breaks off of the immune system, but this means that you have T cells there to begin with. Read more . . .
Pancreatic ductal adenocarcinoma (PDAC) is rapidly metastatic and has proven to be largely unresponsive to current checkpoint blockade, said Stephanie K. Dougan, PhD. However, ongoing research aimed at priming tumor-specific T cells may lead to increased immunogenicity in pancreatic cancer, as well as other poorly immunogenic malignancies.