Pancreatic Cancer: Gene Duplication Explains Tumor Aggressiveness

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Pancreatic cancer is a form of cancer associated with the highest mortality rates in the world.

Genetic changes that could explain his aggressiveness and early metastasis had not been found yet. A team at Technical University of Munich has now shown that those characteristics can be explained by specific gene amplifications which occur along various evolutionary pathways of the cancer.

Based on this discovery, they have derived basic principles underlying the biology of pancreatic cancer.

Until now, scientists have failed to establish a link between the properties of pancreatic cancer, such as its aggressiveness, and changes, i.e. mutations, in the tumor’s genome. Read more . . .