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Nitrogen-Clearing Enzyme a New Target for Difficult-to-Treat Pancreatic Cancers

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While pancreatic cancer is relatively rare in the U.S., it’s also difficult to treat and often deadly. Now researchers at Boston Children’s Hospital are working to cripple the ability of pancreatic tumors to grow by altering their metabolism.

The Boston Children’s team targeted the enzyme arginase 2 (ARG2), which tumors use to clear the excess nitrogen that’s produced when they break down protein. “They need ARG2 to get rid of the extra nitrogen and prevent ammonia from accumulating,” explained Nada Kalaany, an associate professor in pediatrics at Harvard Medical School, who led the research, in a statement. Read more . . .

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