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Immune system infighting explains pancreatic cancer’s aggression

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Conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer, report researchers. Curbing this infighting has the potential to make treatment more effective, according to a study.

The study, which published Aug. 25 in Cell, describes how a powerful subset of immune cells, known as “gamma delta T cells,” prevents other tumor-fighting T cells from entering pancreatic tumors. Without interference from gamma delta T-cells, CD4 and CD8 cells multiply and actively attack tumors the way they attack invading viruses or bacteria. Unfortunately, the immune system generates a large number of pro-tumor gamma delta T cells that infiltrate pancreatic tumors. Read more . . .

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