Genetic Testing of Pancreatic Cyst Fluid Accurately Detects Pre Cancerous and Early Cancer Lesions

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Mayo Clinic researchers have found that a panel of methylated DNA markers in pancreatic cyst fluid can accurately detect advanced precancerous lesions and early cancer in pancreatic cysts. Hypermethylation is a process thought to play a role in silencing of tumor suppressor genes, which are involved in controlling cell growth and division. Uncontrolled cell growth and division can lead to cancer development.

“Pancreatic cysts are common and are often detected incidentally,” says Shounak Majumder, M.B.B.S., a Mayo Clinic gastroenterologist. “The majority of these cysts are benign. However, a subset is premalignant, and the risk of pancreatic cancer in these patients is significantly higher than the general population.” Read more . . .


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