Starving Pancreatic Cancer Cells: Scientists Identify Potential Pancreatic Cancer Target

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Researchers have found that a protein called SLC6A14 is overexpressed by several fold in pancreatic tumors taken from patients and in cancerous pancreatic cells lines compared with normal pancreatic tissue or normal pancreatic cells.

SLC6A14 transports amino acids into cells to help with cellular metabolism.

A blocker of SLC6A14, called α-methyltryptophan, induced amino acid starvation in pancreatic cancer cells and reduced the growth and proliferation of these cells, both in laboratory dishes and in mice. Read more . . .


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