Aggressive Nature of Pancreatic Cancer Linked to Infighting Among Immune Cells

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A specific type of T-cell, called gamma delta T-cells, works to prevent other tumor-fighting T-cells from entering the tumors of pancreatic cancer patients, turning a primary immune system defense mechanism “completely useless in pancreatic cancer,” researchers said.

Without interference from gamma delta T-cells, tumor-attacking T-cells like CD4 and CD8 should be able proliferate and go after pancreatic cancer cells, which they now do not.

The study, “γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation,” recently published in Cell,  was developed by researchers at the New York University (NYU) School of Medicine, and suggests that targeting gamma delta T-cells in pancreatic cancers may improve the work of immunotherapies in boosting tumor-fighting T-cells. Read more . . .

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