How obesity contributes to, blocks treatment of pancreatic cancer

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Massachusetts General Hospital (MGH) investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia — an accumulation of connective tissue — in the most common form of pancreatic cancer.

In their report published online in Cancer Discovery the researchers describe how interactions among fat cells, immune cells and connective tissue cells in obese individuals stimulate a microenvironment that promotes tumor progression while blocking the response to chemotherapy. They also identify a treatment strategy that may inhibit the process. Read more . . .


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