Genetic Mutations and Family History

How do genetic mutations impact treatment? Learn why genetic testing is important for treatment and what the latest research is finding about treatments.

43 Articles

ASCO GI and Let's Win logos
Research
January 29, 2024 • 5 Min

ASCO GI Symposium Features a Broad Range of Pancreatic Cancer Research

Researchers at ASCO GI 2024 reported on research in health disparities, KRAS and other genetic mutations, and novel treatments.

Aqua gloved hands holding lab equipment
Research
January 2, 2024 • 5 Min

Progress and Promise—Research in 2023

What advances were made in 2023 for pancreatic cancer treatments? Where is research headed in the coming year?

Pishvaian
Research
July 27, 2023 • 4 Min

New Study Targets Specific BRAF Mutation

One type of BRAF mutation may provide a target for treatment in pancreatic cancer patients, explains Dr. Michael Pishvaian.

ASCO and Let's Win logos
Research
June 30, 2023 • 5 Min

ASCO 2023: Pancreatic Cancer Research Update

The pancreatic cancer research reports from ASCO 2023 focused on different chemotherapy combinations, including immunotherapy.

Logo of the Basser Center for BRCA
Research
June 19, 2023 • 7 Min

Progress in BRCA-Related Cancers Highlighted By the Basser Center

The Basser Center for BRCA hosted a panel discussion of the latest breakthroughs and discoveries for BRCA-related cancers.

Dr. Ray Wadlow
Research
February 9, 2023 • 5 Min

PRECEDE Trial Sets Survival Rate Goal

Dr. Raymond Wadlow explains how earlier detection of high-risk people is key the PRECEDE trial’s goal to increase pancreatic cancer survival rates.

Dr. Alison Klein, pancreatic cancer researcher
Research
November 7, 2022 • 6 Min

Putting Familial Risk In Perspective

Dr. Alison Klein works to understand the relationship between familial risk and the chances of developing pancreatic cancer.

Dr. Nicolette Rodriguez
Research
October 25, 2022 • 5 Min

Meet the Researcher: Nicolette Juliana Rodriguez, M.D., M.P.H.

Learn more about the research interests of Nicolette Rodriguez, M.D., M.P.H., one of the young investigators Let’s Win sponsored at AACR.

Dr. Andrew Aguirre
Research
September 29, 2022 • 4 Min

Newly Discovered Protein Complex in RAS Pathway May Provide a Treatment Target

Dr. Andrew Aguirre and other researchers from Dana-Farber and the Broad Institute are looking at the RAS pathway for a new target.

bright colored yellow, red, and green dots in square patterns on a black background
Research
June 17, 2022 • 3 Min

New Gene Inhibitor Drug for Patients with MTAP-Deleted Tumors

A new trial targets patients with advanced solid tumors, including pancreatic cancer, with an MTAP-deletion genetic mutation.

Dr. Nicolette Rodriguez
Research
March 21, 2022 • 5 Min

New Study to Get More Minorities Involved in Genetic Testing

Dr. Nicolette Rodriguez leads the REGENERATE study to find the best ways to get more Black and Latinx Americans genetic testing for cancer.

black and white photo of DNA reading
Research
March 11, 2022 • 2 Min

Testing an Approved Drug for a Specific Mutation

Researchers are testing a drug combination for melanoma in pancreatic cancer patients with a BRAF genetic mutation.

Kim Reiss Binder
Research
January 12, 2022 • 5 Min

New Study Aims to Reduce Recurrence Risk for Select Patients

Dr. Kim A. Reiss is leading a study of the PARP inhibitor olaparib to delay or prevent a recurrence of surgically removed pancreatic cancer.

DNA image
Research
November 22, 2021 • 2 Min

Using Molecular Tumor Profiling to Determine the Best Pancreatic Cancer Treatment

A clinical trial looks at whether molecular subtyping of tumors is effective in determining the best pancreatic cancer treatment.

Dr. Pant Subhan
Research
September 1, 2021 • 5 Min

Targeting the Undruggable KRAS Protein

Dr. Shubham Pant is focusing his research on effective treatments for the KRAS mutation, found in 90% of pancreatic cancers.