Finding a Safe Dose of a New Drug for Some Types of Solid Tumors
LMB-100 is a lab-created protein that targets mesothelin. It is being tested against pancreatic cancer and other solid tumors in a clinical trial.
Collaborative Multi-Center Immunotherapy Trial Targets CD40 and PD-1
Dr. Mark O’Hara outlines a collaborative clinical trial of two immunotherapy agents–a checkpoint inhibitor and a monoclonal antibody–plus standard chemotherapy.
Molecular Profiling: Getting to Know Your Tumor
Dr. Johanna Bendell explains the value of molecular profiling. It can indicate which type of chemotherapy will be more successful on your tumor.
The Stroma Presents Challenges and Treatment Opportunities
Dr. Elizabeth Jaffee explains how researchers are approaching penetrating the fibrous stroma around pancreatic tumors, which has long challenged treatment.
Neoantigens Provide New Hope for Pancreatic Cancer Treatments
Vinod Balachandran’s team identified increased T cells in the tumors of long-term pancreatic cancer survivors, with a role for neoantigens in immunotherapy.
Keytruda Runner-Up for Science Breakthrough of the Year
The Lustgarten Foundation shares the story that Keytruda (pembrolizumab) is a runner-up in Science magazine’s Breakthrough of the year.
Testing an Experimental Combination of Drugs
A clinical trial for some cancers including pancreatic cancer tests the effectiveness of a checkpoint inhibitor and an antisense oligonucleotide inhibitor.
Overcoming Challenges to Vaccine Immunotherapy
Modern immunology shows that Coley’s principles of immune stimulation were indeed on target, and today the field of cancer immunology…
More Research Needed for Pancreatic Cancer Immunotherapy
Dr. Luis Diaz provides a status check for immunotherapy treatments for pancreatic cancer, including an explanation of different types.
New SU2C-Lustgarten Foundation Research Team Aims to Apply CAR T Cell Therapy to Pancreatic Cancer
The approach is called chimeric antigen receptor (CAR) T cell therapy, which uses specially modified immune cells to find and…