Genetic Mutations and Family History

705 articles

Research
March 26, 2019 • 4 Min

Damage as a Way to Repair Pancreatic Cancer

Dr. Talia Golan takes a closer look at the damage caused by the BRCA1/2 mutations to find a way to treat pancreatic cancer.

Survivor Stories
August 15, 2016 • 5 Min

The Impact of BRCA Is Broader Than Breast and Ovarian Cancer

Rona Greenberg discusses the impact of BRCA2 on her family, and her search for the best clinical trial for her needs after her pancreatic cancer diagnosis.

Research
June 30, 2023 • 5 Min

ASCO 2023: Pancreatic Cancer Research Update

The pancreatic cancer research reports from ASCO 2023 focused on different chemotherapy combinations, including immunotherapy.

Survivor Stories
May 18, 2016 • 3 Min

Understanding Family History Makes a Difference in Treatment Options

Elizabeth Pršić describes her mother Andrea’s pancreatic cancer treatment. Andrea has the BRCA2 mutation, which helps determine the plan.

Survivor Stories
November 20, 2019 • 6 Min

Tumor RNA Testing Leads to Treatment with a New Drug

When treatment stopped working for Adam Deal, genetic testing of his tumor RNA found a mutation that made him eligible to try a new drug.

Research
September 29, 2022 • 4 Min

Newly Discovered Protein Complex in RAS Pathway May Provide a Treatment Target

Dr. Andrew Aguirre and other researchers from Dana-Farber and the Broad Institute are looking at the RAS pathway for a new target.

Survivor Stories
December 21, 2017 • 5 Min

Using the Energy Around Me to Help Me Heal

Judith Glaser’s genetic mutation influenced her chemotherapy and radiation treatments, supported by the healing energy of friends.

Research
November 1, 2018 • 5 Min

PARP Inhibitors for Pancreatic Cancer Maintenance Treatment

Dr. Kim Reiss Binder is leading a clinical trial of maintenance treatment with the PARP inhibitor rucaparib, for patients who carry the BRCA mutation.

Research
June 27, 2017 • 2 Min

A Maintenance Trial for Patients with BRCA or PALB2 Mutations

A clinical trial examines whether the PARP inhibitor rucaparib can work as a maintenance drug for pancreatic cancer patients with BRCA or PALB2 mutations.

Survivor Stories
November 30, 2020 • 4 Min

A Second Opinion Makes the Difference

Irma Infante refused to give up after a stage IV pancreatic cancer diagnosis. She went for a second opinion and better treatment options.

Research
September 1, 2021 • 5 Min

Targeting the Undruggable KRAS Protein

Dr. Shubham Pant is focusing his research on effective treatments for the KRAS mutation, found in 90% of pancreatic cancers.

Research
January 29, 2024 • 6 Min

ASCO GI Symposium Features a Broad Range of Pancreatic Cancer Research

Researchers at ASCO GI 2024 reported on research in health disparities, KRAS and other genetic mutations, and novel treatments.

Survivor Stories
August 18, 2020 • 4 Min

The Value of Molecular Profiling and Genetic Testing

Gina Harrison underwent molecular profiling of her pancreatic tumor, which led her to a clinical trial. Genetic testing showed her BRCA1 mutation was random.

Survivor Stories
January 3, 2025 • 2 Min

Early Diagnosis Is Important

Jami Curry knew her family history included breast and pancreatic cancer, so she was alert to any health changes.

Survivor Stories
March 28, 2017 • 4 Min

Tailoring My Treatment to My Tumor Genetics

After diagnosis with pancreatic cancer, Sharon Simone had her tumor analyzed. The report on her tumor genetics determined her treatment.