genetic familial mutations
492 articles
Targeted Therapy for Pancreatic Cancer
Dr. Margaret Tempero outlines the work being done in the area of targeted therapy for pancreatic cancer, specifically the testing of ibrutinib.
Predicting Effective Therapy in Pancreatic Cancer
Dr. Kenneth Yu is leading a clinical trial that looks at a pancreatic cancer patient’s pharmacogenomic profile, to see which chemotherapy works better.
Overcoming Challenges to Vaccine Immunotherapy
Dr. Elizabeth Jaffee explains the challenges facing the scientists developing vaccine-based immunotherapy for pancreatic cancer.
The Stroma Presents Challenges and Treatment Opportunities
Dr. Elizabeth Jaffee explains how researchers are approaching penetrating the fibrous stroma around pancreatic tumors, which has long challenged treatment.
Targeting Cancer Metabolism
Researchers from Tyme Technologies are focusing on cancer cell metabolism, particularly tyrosine, as a way to kill cancer cells.
Collaborative Multi-Center Immunotherapy Trial Targets CD40 and PD-1
Dr. Mark O’Hara outlines a collaborative clinical trial of two immunotherapy agents–a checkpoint inhibitor and a monoclonal antibody–plus standard chemotherapy.
Immunology Researchers Solve a Mystery of Metastasis
Physician and researcher Douglas Fearon and his lab have a possible explanation for how cancer cells metastasize, and the role surgery may play in this process.
The Promise of Organoids
Dr. Brian Wolpin explains how organoids are being used to develop personalized treatment for pancreatic cancer patients.
Multicenter Trial Focuses on Neoadjuvant Treatment for Borderline Resectable and Locally Advanced Disease
Dr. David Ryan outlines a new trial for pre-surgical pancreatic cancer treatment combining a blood pressure drug, immunotherapy, standard care and SBRT.
Adjuvant Chemotherapy with Modified FOLFIRINOX Regimen Improves Survival
A French clinical trial showed that adjuvant chemotherapy (given after surgery) with modified FOLFIRINOX improves survival of pancreatic cancer patients.
Tough Tortoise of a Drug Beating Metastatic Pancreatic Cancer
Rexahn Pharmaceuticals is testing RX-3117, a slow-releasing drug similar to gemcitabine, in a clinical trial for metastatic pancreatic cancer patients.
Aiming to Improve Immunotherapy for Pancreatic Cancer
Dr. Deirdre Cohen discusses clinical trials that aim to improve the effectiveness of immunotherapy for pancreatic cancer.
Two Enzymes May Predict Pancreatic Cancer Severity and Development
Dr. Alexandra Newton and her lab have found that the relationship between two enzymes common to cancer may play a role in pancreatic cancer prognosis.
The Link Between Depression and Pancreatic Cancer
Drs. Annette Stanton and Michael Irwin outline the links between depression and pancreatic cancer, both as a symptom of the disease and post-diagnosis.
New Study Combines Checkpoint Inhibitors with Radiation Therapy to Boost Immune Response
Dr. Theodore Hong combines checkpoint inhibitors–a type of immunotherapy–with radiation to boost the immune system in pancreatic cancer treatment.