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Preclinical Study: Three-Step Treatment Strategy for Pancreatic Cancer

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Research led by investigators at Cedars-Sinai Cancer and Johns Hopkins University have discovered a novel three-step treatment that disrupts the pancreatic tumor microenvironment in laboratory mice.  The preclinical study, published in the peer-reviewed journal Gastroenterology, focuses on a trio of drugs that prevented cancer metastasis; the spread of disease to other parts of the body. The preclinical study also is the first to identify synergistic effects of targeting both inside the cell and the tumor microenvironment outside of the cells

“These three drugs, used in combination in a laboratory setting, prevented disease metastasis,” said Arsen Osipov, MD, program lead in the Pancreatic Cancer Multidisciplinary Clinic and Precision Medicine Program at Cedars-Sinai Cancer and senior and corresponding author of the study. “By focusing on the difficult-to-treat tumor microenvironment, we were able to amplify an immune response while simultaneously attacking cancerous cells.” Read more . . . .

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