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Discovery of a Molecular Switch in Pancreatic Cancer Cells that Triggers Metastatic Disease

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More than 62,000 people in the United States will be diagnosed with pancreatic cancer by the end of this year, with the vast majority having a deadly and aggressive subtype known as pancreatic ductal adenocarcinoma (PDA). PDA affects more than 90% of patients with pancreatic cancer and has an average 5-year survival rate of less than 10%.

Now, researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Irving Medical Center have discovered a protein whose level of expression functions as a molecular switch between primary  growth and metastatic dissemination in PDA cells. The study, published online June 24 in Molecular Cell, provides key insights towards a possible treatment that can toggle this molecular switch to block the spread of the disease to other organs. Read more . . .

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