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Scientists Discover Mechanism Controlling Spread of Pancreatic Cancer

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Scientists have shown it is possible to reverse a key process that allows pancreatic cancer cells to grow and spread around the body. These findings, published in Nature, show that a protein called GREM1 is key to regulating the type of cells found in pancreatic cancer – and manipulating its levels can both fuel and reverse the ability of these cells to change into a more aggressive subtype.

The researchers believe this fundamental discovery could ultimately pave the way for new pancreatic cancer treatments. Researchers from The Institute of Cancer Research, London, studied pancreatic cancer with the gene that makes the GREM1 protein switched off in mice, and in pancreatic ‘mini-tumours’, which are also known as organoids. Read more . . . 


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