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Distinct Classes of Fibroblasts in Tumors Play Opposing Roles, Promoting or Restraining Pancreatic Cancer Growth

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Researchers at The University of Texas MD Anderson Cancer Center have discovered that two distinct classes of cancer-associated fibroblasts (CAFs) accumulate in the pancreatic tumor microenvironment and play opposing roles to promote and restrain pancreatic cancer development.

The preclinical findings suggest that appropriately targeting these unique CAF populations may offer strategies to improve the use of other treatments, such as chemotherapy and immunotherapy.  The results were published today in Cancer Discovery, a journal of the American Association for Cancer Research. Read more…

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