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High Local Failure Rates Despite High Margin‐Negative Resection Rates in a Cohort of Borderline Resectable and Locally Advanced Pancreatic Cancer Patients Treated with Stereotactic Body Radiation Therapy Following Multi‐Agent Chemotherapy

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Among patients with borderline resectable and locally advanced pancreatic adenocarcinoma (BRPC/LAPC) treated with induction multi-agent chemotherapy (CTX) followed by stereotactic body radiation therapy (SBRT), margin-negative (R0) resection was successfully achieved in a high proportion of patients but locoregional failure remained common, emphasizing the necessity to continue to optimize radiation delivery in this context.
  • In BRPC/LAPC patients (n= 155) treated at a high-volume institution with induction CTX followed by 5-fraction SBRT, the surgical, pathologic, and survival outcomes were analyzed.

  • Of 64 BRPC patients, 50 (78%) had resection; among those, R0 resection was achieved in 48 (96%) patients.

  • Of 91 LAPC patients, 57 (63%) had resection; R0 resection was achieved in 50 (88%) cases.                                                                                                                                          Read more . . . .

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