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Drug Compound Makes Pancreatic Cancer Cells more Vulnerable to Chemo

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Pancreatic cancer is extremely difficult to treat. By the time it is detected, the cancer often has reached an advanced stage, and patients usually do not survive longer than one year after diagnosis. An aggressive chemotherapy regimen is the first-line treatment, but the side effects can be severe, and many tumors stop responding to treatment.

Now, researchers at Washington University School of Medicine in St. Louis have identified a drug compound that makes pancreatic cancer cells more vulnerable to chemotherapy. Studying mice, they found evidence suggesting that the drug also may reduce some of the damaging side effects of the chemotherapy cocktail FOLFIRINOX (a combination of folinic acid, 5-fluorouracil, irinotecan and oxaliplatin), commonly used to treat pancreatic cancer. Read more . . . 


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