Recently, a class of seven enzymes, called sirtuins, have been shown to be involved in tumour progression. They are capable of modifying other proteins due to their role in regulating metabolism, the tumour microenvironment and the genomic stability of cancer cells. Read more . . .
The reason is that this tumour develops in a particularly hostile microenvironment, with reduced oxygen tension and limited nutrient supply, which leads pancreatic cancer cells to reprogramme their metabolism, thereby gaining proliferative advantages over normal cells.