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Efficient Pre-Treatment for Pancreatic Cancer Using Chloroquine-Loaded Nanoparticles Targeting Pancreatic Stellate Cells

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Pancreatic stellate cells (PSCs) play a key role in desmoplastic stroma, which is a characteristic of pancreatic ductal adenocarcinoma (PDAC), and they also enhance the malignancy of pancreatic cancer cells. Our previous study reported chloroquine’s mitigating effects on PSC activation; however, the drug is known to induce adverse effects in clinical practice.

The present study aimed to reduce chloroquine doses and develop a useful pre-treatment that targets PSCs using nanoparticles. Poly lactic-co-glycolic acid (PLGA) nanoparticles were used as carriers and loaded with indocyanine green (Nano-ICG) or chloroquine (Nano-CQ). Tumor accumulation of Nano-ICG was evaluated using an in vivo imaging system. Read more . . . 

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