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Gene Expression Patterns and Lineage of Metastatic Cancer Traced at Single-Cell Level

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Metastasis often poses cancer’s deadly risk more than the original tumor itself. However, researchers are still studying and understanding the underlying mechanisms behind metastasis. Now, using a mouse model of pancreatic cancer, researchers from the University of Pennsylvania Perelman School of Medicine report they have developed a new method to help trace the lineage and gene expression patterns of individual cancer cells.

“By building a precision tool for probing cancer metastasis in vivo, we’re able to observe previously inaccessible types of information,” explained Kamen Simeonov, an MD-PhD student at the University of Pennsylvania Perelman School of Medicine. “We were able to use this lineage tracing approach to rank cells based on how metastatic they were and then relate these differences in behavior to gene expression changes.” Read more . . . 


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