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Scientists Shrink Pancreatic Tumors by Starving their Cellular ‘Neighbors’

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Scientists at Sanford Burnham Prebys Medical Discovery Institute demonstrated for the first time that blocking “cell drinking,” or macropinocytosis, in the thick tissue surrounding a pancreatic tumor slowed tumor growth–providing more evidence that macropinocytosis is a driver of pancreatic cancer growth and is an important therapeutic target. The study was published in Cancer Discovery, a journal of the American Association for Cancer Research.

“Now that we know that macropinocytosis is ‘revved up’ in both pancreatic cancer cells and the surrounding fibrotic tissue, blocking the process might provide a ‘double whammy’ to pancreatic tumors,” says Cosimo Commisso, Ph.D., associate professor and co-director of the Cell and Molecular Biology of Cancer Program at Sanford Burnham Prebys and senior author of the study. Read more . . . 


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