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Collagen Plays Protective Role during Pancreatic Cancer Development

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Contrary to long-held beliefs, Type I collagen produced by cancer-associated fibroblasts does not promote cancer development but instead plays a protective role in controlling pancreatic cancer progression, reports a new study

“Type I collagen deletion in alphaSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer” in Cancer Cell from researchers at The University of Texas MD Anderson Cancer Center. This new understanding supports novel therapeutic approaches that bolster collagen rather than suppress it, according to the team. Read more . . . 

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