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Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application

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There exists a relationship between a tumor and the immune system, and the latter selectively recognizes and kills tumor cells through immune surveillance.1 Consequently, tumor cells have evolved mechanisms to bypass this process, hijacking the immune system to promote tumor formation.2,3 Therefore, the dual regulation of the immune system in inhibiting and promoting tumorigenesis poses great challenges to treatment prospects.

Cyclic GMP-AMP synthase (cGAS) is a cytoplasmic DNA pattern recognition receptor that has been widely studied in recent years. It regulates downstream immune responses by sensing abnormal DNA in the cytoplasm and plays a dual role in tumor development. Read more . . . 

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