Disruption of cholesterol biosynthesis by Nsdhl knockout or treatment with statins transforms glandular pancreatic carcinomas in mice to the more aggressive basal subtype via the activation of SREBP1. When SREBP1 is cleaved and goes to the nucleus, this induces Tgfb1 expression, autocrine TGF-ß–SMAD2/3 signaling, and epithelial-mesenchymal transition (EMT). Read more . . .
Although a majority of pancreatic cancer cells are highly dependent on endogenous biosynthesis of cholesterol, new research from investigators at Fox Chase Cancer Center has demonstrated that some more aggressive pancreatic cancers are completely independent of this process.