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New Map of the Immune Landscape in Pancreatic Cancer Could Guide Future Personalized Immunotherapy Treatments

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Stubbornly, frustratingly, pancreatic cancer has remained resistant to immunotherapies that are revolutionizing the treatment of many types of cancer. A new study led by the University of Michigan Rogel Cancer Center combined single-cell RNA sequencing with two other investigative techniques to create what is believed to be the most robust and detailed portrait to date of the network of interactions that suppress the body’s immune response in and around pancreatic tumors.

The team’s findings, which appear in the journal Nature Cancer, put a new spotlight on the large degree to which immune response varies from patient to patient and tumor to tumor — which will need to be taken into account as new immunotherapy combinations are developed against the deadly disease. Read more . . . 


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