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Insertional mutagenesis defines drivers and Evolutionary Relationships in Pancreatic Cancer Metastasis

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Metastasis is a defining feature of pancreatic cancer, impacting patient quality of life and therapeutic outcomes. While recurrent mutations in KRAS and TP53 play important roles in primary tumor development and persist in metastases, the contributions of other genes to the metastatic process is understudied.[/subhead

Here, we define a network of metastasis-promoting genes and uncover positively selected genes in metastatic lesions from our Sleeping Beauty mouse model of pancreatic cancer using our recently described SB Driver Analysis statistical pipeline. Read more . . . 

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