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The Potential Roles of Exosomes in Pancreatic Cancer Initiation and Metastasis

The Potential Roles of Exosomes in Pancreatic Cancer Initiation and Metastasis
Pancreatic cancer (PaCa) ranks among the most common and devastating digestive tract cancers worldwide. Besides early surgical resection, no effective regime against this aggressive malignancy has been discovered so far [1]. The 5-year overall survival rate of PaCa is considered less than 5% and the survival period of advanced PaCa is only 3–6 months [2]. Remarkably, the carcinogenesis of PaCa remains poorly characterized.

The majority of PaCa cases (over 85%) are attributed to pancreatic ductal adenocarcinoma (PDAC) [3]. Some studies have shown that acinar-to-ductal metaplasia (ADM), induced by pancreatic injury, pancreatitis, or genetic toxicity, is one of the most typical events observed during PaCa development. ADM can further evolve into a variety of pancreatic intraepithelial neoplasias (PanINs), which are, to some extent, still reversible.  Read more . . . 

 


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