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MicroRNA‑23b‑3p Promotes Pancreatic Cancer Cell Tumorigenesis and Metastasis via the JAK/PI3K and Akt/NF‑κB Signaling Pathways

MicroRNA‑23b‑3p Promotes Pancreatic Cancer Cell Tumorigenesis and Metastasis via the JAK/PI3K and Akt/NF‑κB Signaling Pathways
MicroRNA (miR)‑23b‑3p plays an important role in tumor growth, proliferation, invasion and migration in pancreatic cancer (PC). However, the function and mechanistic role of miR‑23b‑3p in the development of PC remains largely unknown. In the present study, the miR‑23b‑3p levels in the serum of patients with PC were found to be elevated, and the phosphorylation levels of Janus kinase (JAK)2, PI3K, Akt and NF‑κВ were found to be upregulated.

In addition, miR‑23b‑3p was induced in response to interleukin‑6 (IL‑6), which is known to be involved in the progression of PC. Overexpression of miR‑23b‑3p, on the other hand, activated the JAK/PI3K and Akt/NF‑κB signaling pathways in PC cells, as evidenced by miR‑23b‑3p‑induced upregulation of phosphorylated (p‑)JAK2, p‑PI3K, p‑Akt and p‑NF‑κВ, as well as the downregulation of PTEN; and these effects were found to be reversible by miR‑23b‑3p inhibition. Read more . . . 


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