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The Influence of Gut and Tumor Microbiome on Pancreatic Cancer Outcomes

The Influence of Gut and Tumor Microbiome on Pancreatic Cancer Outcomes
Pancreatic cancer is a highly fatal malignancy with overall 5-year survival of under 10%, within the context of increasing incidence rates worldwide (Clin Gastroenterol Hepatol 2020 Mar 5. pii: S1542-3565(20)30276-7 [Epub ahead of print]).

Even among the minority of patients who are diagnosed with early stage disease and undergo resection, most survive less than 5 years (short-term survivors (STS), however a unique subset of patients survive >5 years post-surgery coined long-term survivors (LTS) (Clin Cancer Res 2015;21:1944-1950). Recent human and mice studies suggests that the gut microbiome may play a role in pancreatic cancer initiation and progression through immune system modulation. Read more . . . 


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