David Tuveson and his team wanted to know why pancreatic cancer cells, like many cancer cells, manufacture abundant amounts of cholesterol. Cholesterol is an essential component of cell membranes, but the research team determined that pancreatic cancer cells make far more of it than they need to support their own growth. Read more . . .
Scientists at Cold Spring Harbor Laboratory have found that they can stop the growth of pancreatic cancer cells by interfering with the way the cells store cholesterol. Their findings, published today in the Journal of Experimental Medicine, point toward a new treatment strategy.